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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: We may not be able to make our underlying data set publicly available for legal or ethical reasons.

Received: ApAccepted: MaPublished: April 14, 2022Ĭopyright: © 2022 Xiao et al. PLoS ONE 17(4):Įditor: Susan Horton, University of Waterloo, CANADA

Finally, to assess the cost and effectiveness of DS screening, the total costs were calculated as the sum of screening and diagnosis as well as the direct and indirect economic burden during the average life cycle of DS patients.Ĭitation: Xiao G, Zhao Y, Huang W, Hu L, Wang G, Luo H (2022) Health economic evaluation of noninvasive prenatal testing and serum screening for down syndrome. In strategy IV, all pregnant women received NIPT and those at high risk based on NIPT results had IPD. In strategy III, all pregnant women received SS, and those with T21 risk ≥1,000 had NIPT then, women at high risk based on NIPT results had IPD. In strategy II, all pregnant women received SS, those with T21 risk ≥ 1/270 had IPD, and those with 1/270 > T21 risk ≥ 1/1,000 had NIPT then, women at high risk based on NIPT also had IPD.

In strategy I, all pregnant women received SS, and those with T21 risk ≥1/270 had invasive prenatal diagnosis (IPD). A retrospective analysis was performed on the data of 17,363 pregnant women who received SS and NIPT during gestation in Zhuhai from 2018 to 2019, and a cost-effectiveness analysis was performed with four screening strategies.